研究方向

主要从事天然药物化学专业的教学与科研工作，研究方向为天然药物有效成分提取分离及活性探究，侧重类风湿性关节炎等免疫性疾病的机制研究。

代表性成果

（1）主持项目

国家自然科学基金委员会，青年科学基金项目，82404972，基于ceRNA网络调控p53乳酸化修饰干预TLR4/NF-κB通路探讨镰叶芹醇抑制类风湿关节炎的作用机制 2025-01至2027-12，30万元，在研，主持。

吉林省教育厅，科学研究项目，项目编号：JJKH20251349KJ，名称：Panaxynol靶向miR-9a-5p抑制PFK1基因调控糖酵解改善类风湿关节炎滑膜微环境机制研究 2025-01至2026-12，2.5万元，在研，主持。

吉林省科技厅，吉林省自然科学基金，项目编号：YDZJ202301ZYTS436，名称：基于NFκB/xCT信号通路探讨Panaxynol在类风湿关节炎成纤维滑膜细胞中铁死亡的调控作用及机制 2023-01至2025-12，8万元，在研，主持。

（2）论文专著

1. Tingwen Zhang, Ruihong Zou, Zheng Chen, Yawei Li, Xin Sun, Xialin Sun, Multi-omics reveals that 4′-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota, Phytomedicine, 154 (2026) 158022;

2. Xialin Sun, Tingwen Zhang, Wenhe Zhu, Xinze Jiang, Shijie Wang, Yan Zhao, Xingbo Bian, Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury, International Journal of Biological Macromolecules, 339 (2026) 149819;

3. Xialin Sun, Tingwen Zhang, Yan Zhao, Han Yang, Yawei Li, Xin Sun, Xingbo Bian, A novel glucomannan from Bletilla striata ameliorates colitis: Restores intestinal barrier, alleviates inflammation, and modulates the gut flora, International Journal of Biological Macromolecules, 321 (2025) 146421;

4. Xialin Sun, Jinlong Liu, Shijie Wang, Yan Zhao, Yawei Li, Xin Sun and Tingwen Zhang, Panaxynol from dietary sources modulates ferroptosis through ceRNA networks in synovium: a novel strategy for alleviating rheumatoid arthritis through functional food intervention, Food & Function, 2025, 16, 4104–4121;

5. Tingwen Zhang, Yue Zhong, Yan Shi, Chengcheng Feng, Lu Xu, Zheng Chen, Xin Sun, Yan Zhao, Xialin Sun, Multi-omics reveals that 5-O-methylvisammioside prevention acute liver injury in mice by regulating the TNF/MAPK/NF-κB/arachidonic acid pathway, Phytomedicine 128 (2024) 155550.

（3）专利申请

发明专利：防风多糖及其制备方法与应用，专利号：ZL 2025 1 0704584.9，2 2025年09月19日（授权）

（4）荣誉称号

吉林省E类人才，2023，吉林省人才分类定级评定委员会