研究方向

涵盖酶分子定向进化、基因分子克隆、重组蛋白表达及纯化、功能纳米材料合成、检测技术开发与应用等领域。同时面向校内外师生提供离体组织 Micro-CT扫描与三维结构重建分析等技术服务。

代表性成果

（1）论文发表

[1]Zhang, Lijuan; Ding, Simeng; Tang, Xiuhui; Gao, Renjun; Huo, Rui; Xie, Guiqiu; The Improved Antineoplastic Activity of Thermophilic L-Asparaginase Tli10209 via Site-Directed Mutagenesis, Biomolecules, 2024, 14(6): 686

[2] Tang, Xiuhui; Zhang, Lijuan; Huang, Mingwang; Wang, Fang; Xie, Guiqiu; Huo, Rui; Gao, Renjun; Selective enhanced cytotoxicity of amino acid deprivation for cancer therapy using thermozyme functionalized nanocatalyst, Journal of Nanobiotechnology, 2024, 22(1): 53

[3] Wang, Luoying; Yi, Xingcheng; Cong, Donghang; Long, Mengtuan; Wang, Ping; Zhang, Lijuan; Li, Yupeng; Zhao, Tianyi; Chen, Hongyu; Wang, Song; Zang, Zijun; Zheng, Hanyu; Chen, Shengchao; Fu, Cong; Su, Xiaoyun; Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compoundsegcg and SMRR, Frontiers In Immunology, 2025, 16(1694985)

（2）专利申请

发明专利：基于基因调控网络的单细胞肿瘤微环境数据分析方法,专利号：ZL 2023 1 0296417.6，2023年03月24日